Ligand-induced estrogen receptor α degradation by the proteasome: new actors?
نویسندگان
چکیده
In this perspective we consider new aspects of ligand-induced estrogen receptor alpha (ERalpha) degradation. What are the possible roles of CSN5/Jab1 and the CSN complex in this process? We compare hormone (estrogen) or pure antagonist (fulvestrant) induced degradation of ERalpha and review the effects of kinase-inhibitors and CRM1-dependent nuclear export on ERalpha degradation and transcription activation. A model for ERalpha action integrating these new actors is proposed and the relation between hormone-induced ERalpha degradation and transcription-activation is discussed.
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ورودعنوان ژورنال:
- Nuclear Receptor Signaling
دوره 4 شماره
صفحات -
تاریخ انتشار 2006